Piperonyl butoxide ndiwotchuka kwambiri wothandiziranso tizilombo, kuwonjezera pa nthawi makumi khumi yopititsa patsogolo mankhwala ophera tizilombo titha kuwonjezera nthawi yogwiritsira ntchito, kuonjezera mphamvu yothetsera tizilombo. Piperonyl butyl ether imagwiritsidwa ntchito kwambiri paulimi, thanzi la mabanja komanso mankhwala ophera tizilombo, ndi bungwe lapadera la United Nations lovomerezeka kuti likhale ndi thanzi labwino (kupanga chakudya) mu mankhwala ophera tizilombo toyambitsa matenda.